|
KMID : 0359319970370020389
|
|
Korean Journal of Veterinary Research
1997 Volume.37 No. 2 p.389 ~ p.403
|
|
|
Microbilogy , Antimicrobial drug susceptibility and treatment efficacy in mice against Escherichia coli and Salmonella spp isolated from feces of diarrheal animals
|
|
박종명/Park, Jong Myung
김종만/김종완/김재학/이희수/진영화/권창희/Kim, Jong Man/Kim, Jong Wan/Kim, Jae Hak/Hee Soo/Lee, Jean, Young Hwa/Kweon, Chang Hee
|
|
|
Abstract
|
|
|
Survey on MIC of antimicrobial drugs and its treatment efficacy in mice were conducted for the strains of Escherichia coli and Salmonella spp isolated from feces of young domestic animals with diarrhea in 1996. A total of 338 strains of E coli and 61 strains of Salmonella spp were examined for the susceptibility to 20 antibiotics and 7 synthetic antimicrobial drugs.
The results indicated that the majority of strains were susceptible to amikacin(93.5%), cefoperazone/sulbactam(93.5%), cefotaxim(93.3%), cefomandole(92.8%), cefoperazone(91.6%) and ciprofloxacin(85.1%), in order.
Although gentamicin, ciprofloxacin and norfloxacin showed the relatively low MIC distributions, erythromycin, doxycycline, sulfamethoxazole and oxytetracycline revealed the high MIC distributions to most of isolates.
The MIC_(90) of antimicrobials for E coli were $gt;62.5㎍/㎖ in gentamicin, 2.0㎍/㎖ in ciprofloxacin, 1.0㎍/㎖ in norfloxacin, $gt;500㎍/㎖ in erythromycin, 125㎍/㎖ in doxycycline, $gt;1000㎍/㎖ in sulfamethoxazole and $gt;250μ/㎖ in oxytetracycline.
In general, the MIC of E coli isolates was higher than that of Salmonella spp isolates. Although variation in synergism or additivity of antibiotic combinations were demonstrated, ampicillin-gentamicin was the most efficacious combination both against E coli and Salmonella spp with the fluctuation of 7.7-77.5%.
In the experiment of treatment efficacy in mice, the highest survival ratio(83.3%) after challenge with pathogenic E coli and Salmonella typhimurium was detected in the group treated with gentamicin.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|